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KMID : 1001020190170030195
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Journal of Urologic Oncology
2019 Volume.17 No. 3 p.195 ~ p.198
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Prostate Carcinosarcoma Developing After Combined Pelvic External Beam Radiation Therapy and Androgen Deprivation Therapy
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Kim Young-Joo
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Abstract
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Carcinosarcoma of the prostate is a very rare disease, which consists of carcinomatous and sarcomatous components. The prognosis of patients with prostatic carcinosarcoma is poor. An 80-year-old man who had been suffering from urinary retention and constipation with rectal pain visited a hospital. A patient with a history of combined pelvic external beam radiation therapy (EBRT) and androgen deprivation therapy (ADT) for prostate adenocarcinoma 7 years ago was diagnosed with secondary malignancy such as prostate carcinosarcoma by prostate biopsy. This is also a rare case occurring after combined EBRT and ADT for adenocarcinoma in a short interval. Then, he underwent chemotherapy for one cycle. Chemotherapy was stopped because of rapid clinical aggravation, and the patient died 5 months later. It is important to keep in mind the possibility of carcinosarcoma in the case that prostate-specific antigen maintains stable level but extent of tumor is gradually increased after EBRT or ADT.
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KEYWORD
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Prostate, Carcinosarcoma, Prognosis
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